Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and urea hydrogen peroxide as oxidants
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Jensen_Multistep with SI.pdf
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392.75 KB
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Author(s)
Liu, Xiaoying
Jensen, Klavs F.
Date Issued
April 2013
Journal
Green Chemistry
Publisher
Royal Society of Chemistry
Citation
Liu, Xiaoying, and Klavs F. Jensen. “Multistep Synthesis of Amides from Alcohols and Amines in Continuous Flow Microreactor Systems Using Oxygen and Urea Hydrogen Peroxide as Oxidants.” Green Chemistry 15, no. 6 (2013): 1538.
Version
Author's final manuscript
Abstract
By integrating a heterogeneous oxidation step, gas–liquid separation, and an oxidative amidation reaction to form a continuous system, a multistep synthetic protocol has been demonstrated to produce amides under mild conditions using alcohols and amines as the starting materials. The use of inexpensive oxygen and urea hydrogen peroxide as the only oxidants affords an economical and adaptable synthetic route for amides.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1039/c3gc40407b
