miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
Author(s)Mellios, Nikolaos; Sugihara, Hiroki; Castro, Jorge; Banerjee, Abhishek; Le, Chuong N.; Kumar, Arooshi R.; Crawford, Benjamin; Strathmann, Julia; Tropea, Daniela; Edbauer, Dieter; Sur, Mriganka; Levine, Stuart S.; ... Show more Show less
MetadataShow full item record
Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits.
DepartmentMassachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
Nature Publishing Group
Mellios, Nikolaos, Hiroki Sugihara, Jorge Castro, Abhishek Banerjee, Chuong Le, Arooshi Kumar, Benjamin Crawford, et al. “miR-132, an Experience-Dependent microRNA, Is Essential for Visual Cortex Plasticity.” Nat Neurosci 14, no. 10 (September 4, 2011): 1240–1242.
Author's final manuscript