Rapid Wolff–Kishner reductions in a silicon carbide microreactor
Author(s)Newman, Stephen G.; Gu, Lei; Lesniak, Christoph; Victor, Georg; Meschke, Frank; Abahmane, Lahbib; Jensen, Klavs F.; ... Show more Show less
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Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams.
DepartmentMassachusetts Institute of Technology. Department of Chemical Engineering
Royal Society of Chemistry
Newman, Stephen G., Lei Gu, Christoph Lesniak, Georg Victor, Frank Meschke, Lahbib Abahmane, and Klavs F. Jensen. “Rapid Wolff–Kishner Reductions in a Silicon Carbide Microreactor.” Green Chemistry 16, no. 1 (2013): 176.
Author's final manuscript