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dc.contributor.authorTriantafyllou, Christina
dc.contributor.authorSawyer, Alice T.
dc.contributor.authorHofmann, Stefan G.
dc.contributor.authorGabrieli, John D. E.
dc.contributor.authorAnteraper, Sheeba Rani Arnold
dc.contributor.authorWhitfield-Gabrieli, Susan
dc.date.accessioned2015-02-06T16:25:38Z
dc.date.available2015-02-06T16:25:38Z
dc.date.issued2014-01
dc.identifier.issn2158-0014
dc.identifier.issn2158-0022
dc.identifier.urihttp://hdl.handle.net/1721.1/93896
dc.description.abstractSocial anxiety disorder–related alterations in basal ganglia regions, such as striatum and globus pallidus, though evident from metabolic imaging, remain to be explored using seed-based resting-state functional connectivity magnetic resonance imaging. Capitalizing on the enhanced sensitivity of a multichannel array coil, we collected high-resolution (2-mm isotropic) data from medication-naive patients and healthy control participants. Subcortical resting-state networks from structures including the striatum (caudate and putamen), globus pallidus, thalamus, amygdala, and periaqueductal gray were compared between the two groups. When compared with controls, the caudate seed revealed significantly higher functional connectivity (hyper-connectivity) in the patient group in medial frontal, prefrontal (anterior and dorsolateral), orbito-frontal, and anterior cingulate cortices, which are regions that are typically associated with emotional processing. In addition, with the putamen seed, the patient data exhibited increased connectivity in the fronto-parietal regions (executive control network) and subgenual cingulate (affective network). The globus pallidus seed showed significant increases in connectivity in the patient group, primarily in the precuneus, which is part of the default mode network. Significant hyper-connectivity in the precuneus, interior temporal, and parahippocampal cortices was also observed with the thalamus seed in the patient population, when compared with controls. With amygdala as seed region, between-group differences were primarily in supplementary motor area, inferior temporal gyrus, secondary visual cortex, angular gyrus, and cingulate gyrus. Seed from periaqueductal gray resulted in hyper-connectivity in the patient group, when compared with controls, in dorsolateral prefrontal cortex, precuneus, middle temporal gyrus, and inferior parietal lobule. In all the subcortical regions examined in this study, the control group did not have any significant enhancements in functional connectivity when compared with the patient group.en_US
dc.description.sponsorshipMartinos Imaging Center at MITen_US
dc.language.isoen_US
dc.publisherMary Ann Lieberten_US
dc.relation.isversionofhttp://dx.doi.org/10.1089/brain.2013.0180en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceGabrieli via Courtney Crummetten_US
dc.titleHyper-Connectivity of Subcortical Resting-State Networks in Social Anxiety Disorderen_US
dc.typeArticleen_US
dc.identifier.citationArnold Anteraper, Sheeba, Christina Triantafyllou, Alice T. Sawyer, Stefan G. Hofmann, John D. Gabrieli, and Susan Whitfield-Gabrieli. “Hyper-Connectivity of Subcortical Resting-State Networks in Social Anxiety Disorder.” Brain Connectivity 4, no. 2 (March 2014): 81–90.en_US
dc.contributor.departmentMartinos Imaging Center (McGovern Institute for Brain Research at MIT)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.approverGabrieli, John D. E.en_US
dc.contributor.mitauthorAnteraper, Sheeba Arnolden_US
dc.contributor.mitauthorGabrieli, John D. E.en_US
dc.contributor.mitauthorGabrieli, Susanen_US
dc.relation.journalBrain Connectivityen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsArnold Anteraper, Sheeba; Triantafyllou, Christina; Sawyer, Alice T.; Hofmann, Stefan G.; Gabrieli, John D.; Whitfield-Gabrieli, Susanen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1158-5692
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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