Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands

Author(s)
Bruno, Nicholas C.; Buchwald, Stephen Leffler
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Abstract
A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these palladium sources to various C–N and C–O bond-forming processes is also described.
Date issued
2013-05
URI
http://hdl.handle.net/1721.1/93913
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Bruno, Nicholas C., and Stephen L. Buchwald. “Synthesis and Application of Palladium Precatalysts That Accommodate Extremely Bulky Di- Tert -Butylphosphino Biaryl Ligands.” Org. Lett. 15, no. 11 (June 7, 2013): 2876–2879.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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