Copper-Catalyzed Oxytrifluoromethylation of Unactivated Alkenes
Author(s)Zhu, Rong; Buchwald, Stephen Leffler
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A mild, versatile, and convenient method for the efficient oxytrifluoromethylation of unactivated alkenes based on a copper-catalyzed oxidative difunctionalization strategy has been developed. This methodology provides access to a variety of classes of synthetically useful CF[subscript 3]-containing building blocks from simple starting materials.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of the American Chemical Society
American Chemical Society (ACS)
Zhu, Rong, and Stephen L. Buchwald. “Copper-Catalyzed Oxytrifluoromethylation of Unactivated Alkenes.” Journal of the American Chemical Society 134, no. 30 (August 2012): 12462–12465.
Author's final manuscript