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dc.contributor.authorWestover, M. Brandon
dc.contributor.authorChing, ShiNung
dc.contributor.authorBrown, Emery N.
dc.contributor.authorSolt, Ken
dc.contributor.authorKenny, Jonathan Dillion
dc.date.accessioned2015-02-11T18:39:59Z
dc.date.available2015-02-11T18:39:59Z
dc.date.issued2014-12
dc.date.submitted2014-08
dc.identifier.issn1662-5137
dc.identifier.urihttp://hdl.handle.net/1721.1/94334
dc.description.abstractBurst suppression is an EEG pattern characterized by alternating periods of high-amplitude activity (bursts) and relatively low amplitude activity (suppressions). Burst suppression can arise from several different pathological conditions, as well as from general anesthesia. Here we review current algorithms that are used to quantify burst suppression, its various etiologies, and possible underlying mechanisms. We then review clinical applications of anesthetic-induced burst suppression. Finally, we report the results of our new study showing clear electrophysiological differences in burst suppression patterns induced by two common general anesthetics, sevoflurane and propofol. Our data suggest that the circuit mechanisms that generate burst suppression activity may differ among general anesthetics.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant TR01-GM104948)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant K08-GM094394)en_US
dc.language.isoen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.isversionofhttp://dx.doi.org/10.3389/fnsys.2014.00237en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceFrontiers Research Foundationen_US
dc.titlePropofol and sevoflurane induce distinct burst suppression patterns in ratsen_US
dc.typeArticleen_US
dc.identifier.citationKenny, Jonathan D., M. Brandon Westover, ShiNung Ching, Emery N. Brown, and Ken Solt. “Propofol and Sevoflurane Induce Distinct Burst Suppression Patterns in Rats.” Front. Syst. Neurosci. 8 (December 18, 2014).en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.mitauthorBrown, Emery N.en_US
dc.contributor.mitauthorKenny, Jonathan Dillionen_US
dc.contributor.mitauthorWestover, M. Brandonen_US
dc.contributor.mitauthorSolt, Kenen_US
dc.relation.journalFrontiers in Systems Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKenny, Jonathan D.; Westover, M. Brandon; Ching, ShiNung; Brown, Emery N.; Solt, Kenen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5328-2062
dc.identifier.orcidhttps://orcid.org/0000-0001-9059-0195
dc.identifier.orcidhttps://orcid.org/0000-0003-2668-7819
dc.identifier.orcidhttps://orcid.org/0000-0003-3745-3217
mit.licensePUBLISHER_CCen_US


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