Synthesis of Solid 2-Pyridylzinc Reagents and Their Application in Negishi Reactions

Author(s)
Bernhardt, Sebastian; Stathakis, Christos; Knochel, Paul; Colombe, James Robert; Buchwald, Stephen Leffler
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Abstract
In search of alternatives to unstable or unreliable 2-pyridylboron reagents, we have explored two new varieties of solid, moderately air-stable 2-pyridylzinc reagents. Both reagents can be manipulated in air and are competent nucleophiles in Negishi cross-coupling reactions.
Date issued
2013-11
URI
http://hdl.handle.net/1721.1/94497
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Colombe, James R., Sebastian Bernhardt, Christos Stathakis, Stephen L. Buchwald, and Paul Knochel. “Synthesis of Solid 2-Pyridylzinc Reagents and Their Application in Negishi Reactions.” Org. Lett. 15, no. 22 (November 15, 2013): 5754–5757.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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