Synthesis of Solid 2-Pyridylzinc Reagents and Their Application in Negishi Reactions
Author(s)Bernhardt, Sebastian; Stathakis, Christos; Knochel, Paul; Colombe, James Robert; Buchwald, Stephen Leffler
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In search of alternatives to unstable or unreliable 2-pyridylboron reagents, we have explored two new varieties of solid, moderately air-stable 2-pyridylzinc reagents. Both reagents can be manipulated in air and are competent nucleophiles in Negishi cross-coupling reactions.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Colombe, James R., Sebastian Bernhardt, Christos Stathakis, Stephen L. Buchwald, and Paul Knochel. “Synthesis of Solid 2-Pyridylzinc Reagents and Their Application in Negishi Reactions.” Org. Lett. 15, no. 22 (November 15, 2013): 5754–5757.
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