A General, Practical Palladium-Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides

Author(s)
Senecal, Todd D.; Shu, Wei; Buchwald, Stephen Leffler
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Abstract
Playing it safe: The nontoxic cyanide source K[subscript 4][Fe(CN)[subscript 6]⋅3 H[subscript 2]O can be used for the cyanation of (hetero)aryl halides. The application of palladacycle catalysts prevents poisoning during catalyst formation, thereby allowing for low catalyst loadings, fast reaction times, and wide heterocyclic substrate scope.
Date issued
2013-08
URI
http://hdl.handle.net/1721.1/94498
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Senecal, Todd D., Wei Shu, and Stephen L. Buchwald. “A General, Practical Palladium-Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides.” Angewandte Chemie International Edition 52, no. 38 (August 9, 2013): 10035–10039.
Version: Author's final manuscript
ISSN
14337851
1521-3773
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