Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes
Author(s)
Zhu, Rong; Buchwald, Stephen Leffler
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Something radical: An efficient enantioselective oxytrifluoromethylation of alkenes has been developed using a copper catalyst system. Mechanistic studies are consistent with a metal-catalyzed redox radical addition mechanism in which a C[BOND]O bond is formed by the copper-mediated enantioselective trapping of a prochiral alkyl radical intermediate derived from the initial trifluoromethyl radical addition.
Date issued
2013-10Department
Massachusetts Institute of Technology. Department of ChemistryJournal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Zhu, Rong, and Stephen L. Buchwald. “Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes.” Angewandte Chemie International Edition 52, no. 48 (October 16, 2013): 12655–12658.
Version: Author's final manuscript
ISSN
14337851
1521-3773