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Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes

Author(s)
Zhu, Rong; Buchwald, Stephen Leffler
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Abstract
Something radical: An efficient enantioselective oxytrifluoromethylation of alkenes has been developed using a copper catalyst system. Mechanistic studies are consistent with a metal-catalyzed redox radical addition mechanism in which a C[BOND]O bond is formed by the copper-mediated enantioselective trapping of a prochiral alkyl radical intermediate derived from the initial trifluoromethyl radical addition.
Date issued
2013-10
URI
http://hdl.handle.net/1721.1/94513
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Zhu, Rong, and Stephen L. Buchwald. “Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes.” Angewandte Chemie International Edition 52, no. 48 (October 16, 2013): 12655–12658.
Version: Author's final manuscript
ISSN
14337851
1521-3773

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