dc.contributor.author | Hope, Jennifer M. | |
dc.contributor.author | Wilson, Justin J. | |
dc.contributor.author | Lippard, Stephen J. | |
dc.date.accessioned | 2015-02-19T20:48:20Z | |
dc.date.available | 2015-02-19T20:48:20Z | |
dc.date.issued | 2012-11 | |
dc.date.submitted | 2012-10 | |
dc.identifier.issn | 1477-9226 | |
dc.identifier.issn | 1477-9234 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/95424 | |
dc.description.abstract | A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDIQQH, is reported. The complex, [Pt(BDI[superscript QQ])]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and [superscript 1]H NMR spectroscopy indicate that [Pt(BDI[superscript QQ])]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin. | en_US |
dc.description.sponsorship | National Cancer Institute (U.S.) (Grant CA034992) | en_US |
dc.description.sponsorship | David H. Koch Graduate Fellowship | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant 1S10RR13886) | en_US |
dc.language.iso | en_US | |
dc.publisher | Royal Society of Chemistry, The | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1039/c2dt32462h | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Hope, Jennifer M., Justin J. Wilson, and Stephen J. Lippard. “Photoluminescent DNA Binding and Cytotoxic Activity of a Platinum(ii) Complex Bearing a Tetradentate β-Diketiminate Ligand.” Dalton Transactions 42, no. 9 (2013): 3176. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.mitauthor | Lippard, Stephen J. | en_US |
dc.contributor.mitauthor | Hope, Jennifer M. | en_US |
dc.contributor.mitauthor | Wilson, Justin J. | en_US |
dc.relation.journal | Dalton Transactions | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Hope, Jennifer M.; Wilson, Justin J.; Lippard, Stephen J. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-2693-4982 | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |