Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells
Author(s)Radford, Robert J.; Chyan, Wen; Lippard, Stephen J.
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Combining fluorescent zinc sensors with the facile syntheses and biological targeting capabilities of peptides, we created green- and blue-emitting probes that (i) are readily prepared on the solid-phase, (ii) retain the photophysical and zinc-binding properties of the parent sensor, and (iii) can be directed to the extracellular side of plasma membranes in live cells for detection of mobile zinc.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Royal Society of Chemistry, The
Radford, Robert J., Wen Chyan, and Stephen J. Lippard. “Peptide-Based Targeting of Fluorescent Zinc Sensors to the Plasma Membrane of Live Cells.” Chemical Science 4, no. 8 (2013): 3080. © 2013 Royal Society of Chemistry
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