Synthesis of Spirocyclic Indolines by Interruption of the Bischler–Napieralski Reaction
Author(s)Medley, Jonathan William; Movassaghi, Mohammad
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The development of a versatile method for the synthesis of spirocyclic pyrrolidinoindolines is discussed. Treatment of N-acyltryptamines with trifluoromethanesulfonic anhydride–2-chloropyridine reagent combination affords highly persistent spiroindoleninium ions that are subject to intra- and intermolecular addition at C2 by nucleophiles.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Medley, Jonathan William, and Mohammad Movassaghi. “Synthesis of Spirocyclic Indolines by Interruption of the Bischler–Napieralski Reaction.” Org. Lett. 15, no. 14 (July 19, 2013): 3614–3617.
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