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dc.contributor.authorZhang, Chi
dc.contributor.authorSpokoyny, Alexander M.
dc.contributor.authorZou, Yekui
dc.contributor.authorPentelute, Bradley L.
dc.contributor.authorSimon, Mark
dc.date.accessioned2015-02-25T20:15:29Z
dc.date.available2015-02-25T20:15:29Z
dc.date.issued2013-11
dc.date.submitted2013-09
dc.identifier.issn14337851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/95629
dc.description.abstractSingled out for special treatment: Naturally occurring glutathione S-transferase (GST) was used to catalyze an efficient “click” ligation between polypeptides with an N-terminal glutathione sequence and biomolecules or chemical probes containing perfluorinated aromatic groups (see scheme). The site-specific modification of one cysteine residue was possible in the presence of other unprotected cysteine residues and reactive functional groups.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (GM101762)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Award GM46059)en_US
dc.description.sponsorshipMIT Faculty Start-up Funden_US
dc.description.sponsorshipDamon Runyon Cancer Research Foundationen_US
dc.description.sponsorshipAmgen Inc. (Summer Graduate Research Fellowship)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201306430en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleEnzymatic “Click” Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferaseen_US
dc.typeArticleen_US
dc.identifier.citationZhang, Chi, Alexander M. Spokoyny, Yekui Zou, Mark D. Simon, and Bradley L. Pentelute. “Enzymatic ‘Click’ Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferase.” Angewandte Chemie International Edition 52, no. 52 (November 12, 2013): 14001–14005.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorZhang, Chien_US
dc.contributor.mitauthorSpokoyny, Alexander M.en_US
dc.contributor.mitauthorZou, Yekuien_US
dc.contributor.mitauthorSimon, Marken_US
dc.contributor.mitauthorPentelute, Bradley L.en_US
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsZhang, Chi; Spokoyny, Alexander M.; Zou, Yekui; Simon, Mark D.; Pentelute, Bradley L.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9519-7456
dc.identifier.orcidhttps://orcid.org/0000-0003-1632-5195
mit.licenseOPEN_ACCESS_POLICYen_US


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