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The Microbial Opsin Family of Optogenetic Tools

dc.contributor.authorZhang, Feng
dc.contributor.authorVierock, Johannes
dc.contributor.authorYizhar, Ofer
dc.contributor.authorFenno, Lief E.
dc.contributor.authorTsunoda, Satoshi
dc.contributor.authorKianianmomeni, Arash
dc.contributor.authorPrigge, Matthias
dc.contributor.authorBerndt, Andre
dc.contributor.authorCushman, John
dc.contributor.authorPolle, Jürgen
dc.contributor.authorMagnuson, Jon
dc.contributor.authorHegemann, Peter
dc.contributor.authorDeisseroth, Karl
dc.date.accessioned2015-03-04T15:27:04Z
dc.date.available2015-03-04T15:27:04Z
dc.date.issued2011-12
dc.identifier.issn00928674
dc.identifier.issn1097-4172
dc.identifier.urihttp://hdl.handle.net/1721.1/95788
dc.description.abstractThe capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (TR01)en_US
dc.description.sponsorshipBill & Melinda Gates Foundationen_US
dc.description.sponsorshipSimons Foundationen_US
dc.description.sponsorshipDamon Runyon Cancer Research Foundationen_US
dc.description.sponsorshipMcKnight Foundationen_US
dc.description.sponsorshipRobert Metcalfeen_US
dc.description.sponsorshipHelen S. Boylan Foundationen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cell.2011.12.004en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevieren_US
dc.titleThe Microbial Opsin Family of Optogenetic Toolsen_US
dc.typeArticleen_US
dc.identifier.citationZhang, Feng, Johannes Vierock, Ofer Yizhar, Lief E. Fenno, Satoshi Tsunoda, Arash Kianianmomeni, Matthias Prigge, et al. “The Microbial Opsin Family of Optogenetic Tools.” Cell 147, no. 7 (December 2011): 1446–1457. © 2011 Elsevier Inc.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorZhang, Fengen_US
dc.relation.journalCellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsZhang, Feng; Vierock, Johannes; Yizhar, Ofer; Fenno, Lief E.; Tsunoda, Satoshi; Kianianmomeni, Arash; Prigge, Matthias; Berndt, Andre; Cushman, John; Polle, Jürgen; Magnuson, Jon; Hegemann, Peter; Deisseroth, Karlen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-2782-2509
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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