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Multimonth controlled small molecule release from biodegradable thin films

Author(s)
Hammond, Paula T.; Hsu, Bryan Boen; Hagerman, Samantha R.; Park, Myoung-Hwan
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Abstract
Long-term, localized delivery of small molecules from a biodegradable thin film is challenging owing to their low molecular weight and poor charge density. Accomplishing highly extended controlled release can facilitate high therapeutic levels in specific regions of the body while significantly reducing the toxicity to vital organs typically caused by systemic administration and decreasing the need for medical intervention because of its long-lasting release. Also important is the ability to achieve high drug loadings in thin film coatings to allow incorporation of significant drug amounts on implant surfaces. Here we report a sustained release formulation for small molecules based on a soluble charged polymer–drug conjugate that is immobilized into nanoscale, conformal, layer-by-layer assembled films applicable to a variety of substrate surfaces. We measured a highly predictable sustained drug release from a polymer thin film coating of 0.5–2.7 μm that continued for more than 14 mo with physiologically relevant drug concentrations, providing an important drug delivery advance. We demonstrated this effect with a potent small molecule nonsteroidal anti-inflammatory drug, diclofenac, because this drug can be used to address chronic pain, osteoarthritis, and a range of other critical medical issues.
Date issued
2014-08
URI
http://hdl.handle.net/1721.1/95790
Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry; Koch Institute for Integrative Cancer Research at MIT
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Hsu, Bryan B., Myoung-Hwan Park, Samantha R. Hagerman, and Paula T. Hammond. “Multimonth Controlled Small Molecule Release from Biodegradable Thin Films.” Proceedings of the National Academy of Sciences 111, no. 33 (August 4, 2014): 12175–12180.
Version: Final published version
ISSN
0027-8424
1091-6490

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