A Synaptic Strategy for Consolidation of Convergent Visuotopic Maps
Author(s)Phillips, Marnie A.; Colonnese, Matthew T.; Goldberg, Julie; Lewis, Laura D.; Brown, Emery N.; Constantine-Paton, Martha; ... Show more Show less
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The mechanisms by which experience guides refinement of converging afferent pathways are poorly understood. We describe a vision-driven refinement of corticocollicular inputs that determines the consolidation of retinal and visual cortical (VC) synapses on individual neurons in the superficial superior colliculus (sSC). Highly refined corticocollicular terminals form 1–2 days after eye-opening (EO), accompanied by VC-dependent filopodia sprouting on proximal dendrites, and PSD-95 and VC-dependent quadrupling of functional synapses. Delayed EO eliminates synapses, corticocollicular terminals, and spines on VC-recipient dendrites. Awake recordings after EO show that VC and retina cooperate to activate sSC neurons, and VC light responses precede sSC responses within intervals promoting potentiation. Eyelid closure is associated with more protracted cortical visual responses, causing the majority of VC spikes to follow those of the colliculus. These data implicate spike-timing plasticity as a mechanism for cortical input survival, and support a cooperative strategy for retinal and cortical coinnervation of the sSC.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; McGovern Institute for Brain Research at MIT
Phillips, Marnie A., Matthew T. Colonnese, Julie Goldberg, Laura D. Lewis, Emery N. Brown, and Martha Constantine-Paton. “A Synaptic Strategy for Consolidation of Convergent Visuotopic Maps.” Neuron 71, no. 4 (August 2011): 710–724. © 2011 Elsevier Inc.
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