dc.contributor.author | Pan, Enhui | |
dc.contributor.author | Zhang, Xiao-an | |
dc.contributor.author | Huang, Zhen | |
dc.contributor.author | Krezel, Artur | |
dc.contributor.author | Zhao, Min | |
dc.contributor.author | Tinberg, Christine E. | |
dc.contributor.author | Lippard, Stephen J. | |
dc.contributor.author | McNamara, James O. | |
dc.date.accessioned | 2015-03-04T19:26:10Z | |
dc.date.available | 2015-03-04T19:26:10Z | |
dc.date.issued | 2011-09 | |
dc.date.submitted | 2011-07 | |
dc.identifier.issn | 08966273 | |
dc.identifier.issn | 1097-4199 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/95813 | |
dc.description.abstract | The presence of zinc in glutamatergic synaptic vesicles of excitatory neurons of mammalian cerebral cortex suggests that zinc might regulate plasticity of synapses formed by these neurons. Long-term potentiation (LTP) is a form of synaptic plasticity that may underlie learning and memory. We tested the hypothesis that zinc within vesicles of mossy fibers (mf) contributes to mf-LTP, a classical form of presynaptic LTP. We synthesized an extracellular zinc chelator with selectivity and kinetic properties suitable for study of the large transient of zinc in the synaptic cleft induced by mf stimulation. We found that vesicular zinc is required for presynaptic mf-LTP. Unexpectedly, vesicular zinc also inhibits a form of postsynaptic mf-LTP. Because the mf-CA3 synapse provides a major source of excitatory input to the hippocampus, regulating its efficacy by these dual actions, vesicular zinc is critical to proper function of hippocampal circuitry in health and disease. | en_US |
dc.description.sponsorship | National Institute of General Medical Sciences (U.S.) (Grant GM065519) | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.neuron.2011.07.019 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Elsevier | en_US |
dc.title | Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Pan, Enhui, Xiao-an Zhang, Zhen Huang, Artur Krezel, Min Zhao, Christine E. Tinberg, Stephen J. Lippard, and James O. McNamara. “Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse.” Neuron 71, no. 6 (September 2011): 1116–1126. © 2011 Elsevier Inc. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.mitauthor | Zhang, Xiao-an | en_US |
dc.contributor.mitauthor | Huang, Zhen | en_US |
dc.contributor.mitauthor | Zhao, Min | en_US |
dc.contributor.mitauthor | Tinberg, Christine E. | en_US |
dc.contributor.mitauthor | Lippard, Stephen J. | en_US |
dc.relation.journal | Neuron | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Pan, Enhui; Zhang, Xiao-an; Huang, Zhen; Krezel, Artur; Zhao, Min; Tinberg, Christine E.; Lippard, Stephen J.; McNamara, James O. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-2693-4982 | |
dspace.mitauthor.error | true | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |