Wireless Magnetothermal Deep Brain Stimulation
Author(s)Chen, Ritchie; Romero Uribe, Gabriela; Christiansen, Michael Gary; Mohr, Alan C.; Anikeeva, Polina Olegovna
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Wireless deep brain stimulation of well-defined neuronal populations could facilitate the study of intact brain circuits and the treatment of neurological disorders. Here we demonstrate minimally-invasive and remote neural excitation through the activation of the heat-sensitive capsaicin receptor TRPV1 by magnetic nanoparticles. When exposed to alternating magnetic fields, the nanoparticles dissipate heat generated by hysteresis, triggering widespread and reversible firing of TRPV1+ neurons. Wireless magnetothermal stimulation in the ventral tegmental area of mice evoked excitation in subpopulations of neurons in the targeted brain region and in structures receiving excitatory projections. The nanoparticles persisted in the brain for over a month, allowing for chronic stimulation without the need for implants and connectors.
DepartmentMassachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Massachusetts Institute of Technology. Research Laboratory of Electronics
American Association for the Advancement of Science (AAAS)
Chen, Ritchie, Gabriela Romero, Michael G. Christiansen, Alan Mohr, and Polina Anikeeva. Wireless magnetothermal deep brain stimulation. Science 347.6229 (March 27, 2015), pp. 1477-1480.
Author's final manuscript