| dc.contributor.author | Zhang, Chen | |
| dc.contributor.author | Jang, Sunyoung | |
| dc.contributor.author | Amadi, Ovid C. | |
| dc.contributor.author | Shimizu, Koichi | |
| dc.contributor.author | Lee, Richard T. | |
| dc.contributor.author | Mitchell, Richard Neal | |
| dc.date.accessioned | 2015-03-20T13:58:53Z | |
| dc.date.available | 2015-03-20T13:58:53Z | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-04 | |
| dc.identifier.issn | 2314-6133 | |
| dc.identifier.issn | 2314-6141 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/96105 | |
| dc.description.abstract | Existing chemotaxis assays do not generate stable chemotactic gradients and thus—over time—functionally measure only nonspecific random motion (chemokinesis). In comparison, microfluidic technology has the capacity to generate a tightly controlled microenvironment that can be stably maintained for extended periods of time and is, therefore, amenable to adaptation for assaying chemotaxis. We describe here a novel microfluidic device for sensitive assay of cellular migration and show its application for evaluating the chemotaxis of smooth muscle cells in a chemokine gradient. | en_US |
| dc.description.sponsorship | Brigham and Women's Hospital (Brigham Research Institute Fund to Sustain Research Excellence-Bridge Research Grant) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (Science and Technology Center CBET-0939511) | en_US |
| dc.publisher | Hindawi Publishing Corporation | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1155/2013/373569 | en_US |
| dc.rights | Creative Commons Attribution | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | en_US |
| dc.source | Hindawi Publishing Corporation | en_US |
| dc.title | A Sensitive Chemotaxis Assay Using a Novel Microfluidic Device | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Zhang, Chen et al. “A Sensitive Chemotaxis Assay Using a Novel Microfluidic Device.” BioMed Research International 2013 (2013): 1–8. | en_US |
| dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
| dc.contributor.mitauthor | Amadi, Ovid C. | en_US |
| dc.relation.journal | BioMed Research International | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2015-03-19T11:34:29Z | |
| dc.language.rfc3066 | en | |
| dc.rights.holder | Copyright © 2013 Chen Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
| dspace.orderedauthors | Zhang, Chen; Jang, Sunyoung; Amadi, Ovid C.; Shimizu, Koichi; Lee, Richard T.; Mitchell, Richard N. | en_US |
| mit.license | PUBLISHER_CC | en_US |
| mit.metadata.status | Complete | |
