| dc.contributor.author | Hanna, Jacob | |
| dc.contributor.author | Saha, Krishanu | |
| dc.contributor.author | Jaenisch, Rudolf | |
| dc.date.accessioned | 2015-03-20T14:11:03Z | |
| dc.date.available | 2015-03-20T14:11:03Z | |
| dc.date.issued | 2010-11 | |
| dc.identifier.issn | 00928674 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/96107 | |
| dc.description.abstract | Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripotency can interconvert through the modulation of both cell-intrinsic and exogenous factors. To fully realize the potential of in vitro reprogrammed cells, we need to understand the molecular and epigenetic determinants that convert one cell type into another. Here we review recent advances in this rapidly moving field and emphasize unresolved and controversial questions. | en_US |
| dc.description.sponsorship | Genzyme Corporation (Fellowship) | en_US |
| dc.description.sponsorship | Helen Hay Whitney Foundation (Fellowship) | en_US |
| dc.description.sponsorship | Swiss Federal Institute of Technology Zurich (Society in Science: Branco-Weiss fellowship) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier B.V. | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.cell.2010.10.008 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Elsevier | en_US |
| dc.title | Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Hanna, Jacob H., Krishanu Saha, and Rudolf Jaenisch. “Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues.” Cell 143, no. 4 (November 2010): 508–525. © 2010 Elsevier Inc. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Whitehead Institute for Biomedical Research | en_US |
| dc.contributor.mitauthor | Hanna, Jacob | en_US |
| dc.contributor.mitauthor | Saha, Krishanu | en_US |
| dc.contributor.mitauthor | Jaenisch, Rudolf | en_US |
| dc.relation.journal | Cell | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Hanna, Jacob H.; Saha, Krishanu; Jaenisch, Rudolf | en_US |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
