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dc.contributor.authorBertrand III, F. E.
dc.contributor.authorOlson, S. L.
dc.contributor.authorWillett, C. E.
dc.contributor.authorWu, G. E.
dc.date.accessioned2015-03-20T17:13:27Z
dc.date.available2015-03-20T17:13:27Z
dc.date.issued1998
dc.date.submitted1997-01
dc.identifier.issn1044-6672
dc.identifier.urihttp://hdl.handle.net/1721.1/96130
dc.description.abstractThe recombination activating genes, rag1 and rag2 are essential for the rearrangement of antigen receptor V, D, and J gene segments (Oettinger et al., 1990, Mombaerts et al., 1992; Sehatz and Oettinger, 1992; Shinkai et al., 1992). Both genes are found in all species that are known to rearrange their antigenspecific receptors. The coding regions as well as the genomic organization of the rag locus are highly conserved throughout evolution. Rag1 and rag2, which are convergently transcribed, are separated by an intergenic region of DNA that varies in size among species, being, for example, about 11 kb in the human (Homo sapiens), 8 kb in the mouse (Mus musculus), 5.2 kb in the frog (Xenopus laevis), 2.8 kb in the rainbow trout (Oncorhynchus mykiss) (Oettinger et al., 1990; Ichicara et al., 1992; Greenhalgh et al., 1993; Greenhalgh and Steiner., 1995; Hansen and Kaattari, 1996), and 2.6 kb in the zebrafish (Danio rerio).en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 2R01 AI08054)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 5T32 AI07436)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 1F32 AI09072)en_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionofhttp://dx.doi.org/10.1155/1998/96749en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.sourceHindawi Publishing Corporationen_US
dc.titleSequence of the RAG1 and RAG2 Intergenic Region in Zebrafish (Danio rerio)en_US
dc.typeArticleen_US
dc.identifier.citationBertrand III, F. E., S. L. Olson, C. E. Willett, and G. E. Wu. “Sequence of the RAG1 and RAG2 Intergenic Region in Zebrafish (Danio Rerio).” Developmental Immunology 5, no. 3 (1998): 211–214. © 1998 Hindawi Publishing Corporationen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorWillett, C. E.en_US
dc.relation.journalDevelopmental Immunologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2015-03-19T11:37:35Z
dc.language.rfc3066en
dc.rights.holderCopyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dspace.orderedauthorsBertrand III, F. E.; Olson, S. L.; Willett, C. E.; Wu, G. E.en_US
mit.licensePUBLISHER_CCen_US


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