Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast
Author(s)Kinde, B.; Unal, Elcin; Amon, Angelika B
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Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same replicative potential as gametes generated by young cells. Age-associated damage is no longer detectable in mature gametes. Furthermore, transient induction of a transcription factor essential for later stages of gametogenesis extends the replicative life span of aged cells. Our results indicate that gamete formation brings about rejuvenation by eliminating age-induced cellular damage.
DepartmentMassachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
American Association for the Advancement of Science (AAAS)
Unal, E., B. Kinde, and A. Amon. “Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast.” Science 332, no. 6037 (June 23, 2011): 1554–1557.
Author's final manuscript