MicroRNAs and Cancer: Short RNAs Go a Long Way
Author(s)Ventura, Andrea; Jacks, Tyler E.
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MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, contribute to tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations of individual miRNAs are found in some tumors. Functional studies are now elucidating the mechanism of action of putative oncogenic and tumor suppressor miRNAs.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
Ventura, Andrea, and Tyler Jacks. “MicroRNAs and Cancer: Short RNAs Go a Long Way.” Cell 136, no. 4 (February 2009): 586–591. © 2009 Elsevier Inc.
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