Wnt Signaling and the Polarity of the Primary Body Axis
Author(s)Petersen, Christian P.; Reddien, Peter
MetadataShow full item record
How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (protostomes) suggest that Wnt signaling through β-catenin controls posterior identity during body plan formation in most bilaterally symmetric animals. Wnt signaling also influences primary axis polarity of pre-bilaterian animals, indicating that an axial patterning role for Wnt signaling predates the evolution of bilaterally symmetric animals. The use of posterior Wnt signaling and anterior Wnt inhibition might be a unifying principle of body plan development in most animals.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Petersen, Christian P., and Peter W. Reddien. “Wnt Signaling and the Polarity of the Primary Body Axis.” Cell 139, no. 6 (December 2009): 1056–1068. © 2009 Elsevier Inc.
Final published version