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dc.contributor.authorSaha, Krishanu
dc.contributor.authorJaenisch, Rudolf
dc.date.accessioned2015-03-25T16:51:24Z
dc.date.available2015-03-25T16:51:24Z
dc.date.issued2009-12
dc.identifier.issn19345909
dc.identifier.urihttp://hdl.handle.net/1721.1/96182
dc.description.abstractReprogramming of human somatic cells uses readily accessible tissue, such as skin or blood, to generate embryonic-like induced pluripotent stem cells (iPSCs). This procedure has been applied to somatic cells from patients who are classified into a disease group, thus creating “disease-specific” iPSCs. Here, we examine the challenges and assumptions in creating a disease model from a single cell of the patient. Both the kinetics of disease onset and progression as well as the spatial localization of disease in the patient's body are challenges to disease modeling. New tools in genetic modification, reprogramming, biomaterials, and animal models can be used for addressing these challenges.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant RO1-HD045022)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R37-CA084198)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (Grant RO1-CA087869)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.stem.2009.11.009en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevieren_US
dc.titleTechnical Challenges in Using Human Induced Pluripotent Stem Cells to Model Diseaseen_US
dc.typeArticleen_US
dc.identifier.citationSaha, Krishanu, and Rudolf Jaenisch. “Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease.” Cell Stem Cell 5, no. 6 (December 2009): 584–595. © 2009 Elsevier Inc.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorJaenisch, Rudolfen_US
dc.relation.journalCell Stem Cellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSaha, Krishanu; Jaenisch, Rudolfen_US
mit.licensePUBLISHER_POLICYen_US


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