A Feud that Wasn't: Acetylcholine Evokes Dopamine Release in the Striatum
Author(s)Surmeier, D. James; Graybiel, Ann M.
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In this issue of Neuron, Threlfell et al. (2012) report that synchronous activation of cholinergic interneurons evokes striatal dopamine release by activating presynaptic nicotinic acetylcholine receptors. These findings call for a fundamental reevaluation of the long-standing view that dopamine and acetylcholine “feud” over control of striatal circuitry.
DepartmentMcGovern Institute for Brain Research at MIT
Surmeier, D. James, and Ann M. Graybiel. “A Feud That Wasn’t: Acetylcholine Evokes Dopamine Release in the Striatum.” Neuron 75, no. 1 (July 2012): 1–3. © 2012 Elsevier Inc.
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