Sickle Cell MicroRNAs Inhibit the Malaria Parasite
Author(s)Duraisingh, Manoj T.; Lodish, Harvey F.
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Sickle cell hemoglobin conveys resistance to malaria. In this issue of Cell Host & Microbe, LaMonte et al. (2012) demonstrate a surprising mechanism for this innate immunity. A microRNA enriched in sickle red blood cells is translocated into the parasite, incorporated covalently into P. falciparum mRNAs and inhibits parasite growth.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Cell Host & Microbe
Duraisingh, Manoj T., and Harvey F. Lodish. “Sickle Cell MicroRNAs Inhibit the Malaria Parasite.” Cell Host & Microbe 12, no. 2 (August 2012): 127–128. © 2012 Elsevier Inc.
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