Hippocampal Replay of Extended Experience
Author(s)
Davidson, Thomas J.; Kloosterman, Fabian; Wilson, Matthew A.
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During pauses in exploration, ensembles of place cells in the rat hippocampus re-express firing sequences corresponding to recent spatial experience. Such “replay” co-occurs with ripple events: short-lasting (∼50–120 ms), high-frequency (∼200 Hz) oscillations that are associated with increased hippocampal-cortical communication. In previous studies, rats exploring small environments showed replay anchored to the rat's current location and compressed in time into a single ripple event. Here, we show, using a neural decoding approach, that firing sequences corresponding to long runs through a large environment are replayed with high fidelity and that such replay can begin at remote locations on the track. Extended replay proceeds at a characteristic virtual speed of ∼8 m/s and remains coherent across trains of ripple events. These results suggest that extended replay is composed of chains of shorter subsequences, which may reflect a strategy for the storage and flexible expression of memories of prolonged experience.
Date issued
2009-08Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and MemoryJournal
Neuron
Publisher
Elsevier B.V.
Citation
Davidson, Thomas J., Fabian Kloosterman, and Matthew A. Wilson. “Hippocampal Replay of Extended Experience.” Neuron 63, no. 4 (August 2009): 497–507. © 2009 Elsevier Inc.
Version: Final published version
ISSN
08966273