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dc.contributor.authorGhosh, Debadyuti
dc.contributor.authorNa, Young Jeong
dc.contributor.authorBirrer, Michael J.
dc.contributor.authorBagley, Alexander F
dc.contributor.authorBhatia, Sangeeta N
dc.contributor.authorBelcher, Angela M
dc.date.accessioned2015-04-01T16:53:13Z
dc.date.available2015-04-01T16:53:13Z
dc.date.issued2014-09
dc.date.submitted2014-01
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/96311
dc.description.abstractHighly sensitive detection of small, deep tumors for early diagnosis and surgical interventions remains a challenge for conventional imaging modalities. Second-window near-infrared light (NIR2, 950–1,400 nm) is promising for in vivo fluorescence imaging due to deep tissue penetration and low tissue autofluorescence. With their intrinsic fluorescence in the NIR2 regime and lack of photobleaching, single-walled carbon nanotubes (SWNTs) are potentially attractive contrast agents to detect tumors. Here, targeted M13 virus-stabilized SWNTs are used to visualize deep, disseminated tumors in vivo. This targeted nanoprobe, which uses M13 to stably display both tumor-targeting peptides and an SWNT imaging probe, demonstrates excellent tumor-to-background uptake and exhibits higher signal-to-noise performance compared with visible and near-infrared (NIR1) dyes for delineating tumor nodules. Detection and excision of tumors by a gynecological surgeon improved with SWNT image guidance and led to the identification of submillimeter tumors. Collectively, these findings demonstrate the promise of targeted SWNT nanoprobes for noninvasive disease monitoring and guided surgery.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). Center for Nanotechnology Excellence (Grant U54-CA119349-04)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). Center for Nanotechnology Excellence (Grant U54-CA151884)en_US
dc.description.sponsorshipDavid H. Koch Institute for Integrative Cancer Research at MIT. Frontier Research Program (Kathy and Curt Marble Cancer Research Fund)en_US
dc.description.sponsorshipNational Institute of Environmental Health Sciences (Grant P30-ES002109)en_US
dc.description.sponsorshipMarie D. & Pierre Casimir-Lambert Funden_US
dc.description.sponsorshipAmar G. Bose Research Granten_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1400821111en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceNational Academy of Sciences (U.S.)en_US
dc.titleDeep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubesen_US
dc.typeArticleen_US
dc.identifier.citationGhosh, D., A. F. Bagley, Y. J. Na, M. J. Birrer, S. N. Bhatia, and A. M. Belcher. “Deep, Noninvasive Imaging and Surgical Guidance of Submillimeter Tumors Using Targeted M13-Stabilized Single-Walled Carbon Nanotubes.” Proceedings of the National Academy of Sciences 111, no. 38 (September 11, 2014): 13948–13953.en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorGhosh, Debadyutien_US
dc.contributor.mitauthorBagley, Alexander F.en_US
dc.contributor.mitauthorBhatia, Sangeeta N.en_US
dc.contributor.mitauthorBelcher, Angela M.en_US
dc.relation.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGhosh, D.; Bagley, A. F.; Na, Y. J.; Birrer, M. J.; Bhatia, S. N.; Belcher, A. M.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9353-7453
dc.identifier.orcidhttps://orcid.org/0000-0002-0930-302X
dc.identifier.orcidhttps://orcid.org/0000-0002-1293-2097
mit.licensePUBLISHER_POLICYen_US


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