MicroRNAs: Target Recognition and Regulatory Functions

Author(s)
Bartel, David
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Abstract
MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
Date issued
2009-01
URI
http://hdl.handle.net/1721.1/96383
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Cell
Publisher
Elsevier B.V.
Citation
Bartel, David P. “MicroRNAs: Target Recognition and Regulatory Functions.” Cell 136, no. 2 (January 2009): 215–233. © 2009 Elsevier Inc.
Version: Final published version
ISSN
00928674
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