Unraveling Tumor Suppressor Networks with In Vivo RNAi

Author(s)
Braun, Christian Joerg; Hemann, Michael
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Abstract
BMI1 is a known oncogenic transcriptional repressor in glioblastoma stem-like cells, but its downstream mediators are poorly understood. Recently, in Cancer Cell, Gargiulo et al. (2013) designed a rational in vivo RNAi screen based on BMI1 ChIP-seq from neural progenitors and identified functional tumor suppressor targets, including Atf3 and Cbx7.
Date issued
2013-06
URI
http://hdl.handle.net/1721.1/96413
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Braun, Christian J., and Michael T. Hemann. “Unraveling Tumor Suppressor Networks with In Vivo RNAi.” Cell Stem Cell 12, no. 6 (June 2013): 639–641. © 2013 Elsevier Inc.
Version: Final published version
ISSN
19345909
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