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dc.contributor.authorLakritz, Jessica
dc.contributor.authorPoutahidis, Theofilos
dc.contributor.authorLevkovich, Tatiana
dc.contributor.authorChatzigiagkos, Antonis
dc.contributor.authorMirabal, Sheyla
dc.contributor.authorAlm, Eric J.
dc.contributor.authorErdman, Susan E.
dc.contributor.authorVarian, Bernard
dc.contributor.authorIbrahim, Yassin
dc.date.accessioned2015-04-09T19:54:31Z
dc.date.available2015-04-09T19:54:31Z
dc.date.issued2014-01
dc.date.submitted2013-07
dc.identifier.issn00207136
dc.identifier.issn1097-0215
dc.identifier.urihttp://hdl.handle.net/1721.1/96512
dc.description.abstractRecent studies suggest health benefits including protection from cancer after eating fermented foods such as probiotic yogurt, though the mechanisms are not well understood. Here we tested mechanistic hypotheses using two different animal models: the first model studied development of mammary cancer when eating a Westernized diet, and the second studied animals with a genetic predilection to breast cancer. For the first model, outbred Swiss mice were fed a Westernized chow putting them at increased risk for development of mammary tumors. In this Westernized diet model, mammary carcinogenesis was inhibited by routine exposure to Lactobacillus reuteri ATCC-PTA-6475 in drinking water. The second model was FVB strain erbB2 (HER2) mutant mice, genetically susceptible to mammary tumors mimicking breast cancers in humans, being fed a regular (non-Westernized) chow diet. We found that oral supplement with these purified lactic acid bacteria alone was sufficient to inhibit features of mammary neoplasia in both models. The protective mechanism was determined to be microbially-triggered CD4+CD25+ lymphocytes. When isolated and transplanted into other subjects, these L. reuteri-stimulated lymphocytes were sufficient to convey transplantable anti-cancer protection in the cell recipient animals. These data demonstrate that host immune responses to environmental microbes significantly impact and inhibit cancer progression in distal tissues such as mammary glands, even in genetically susceptible mice. This leads us to conclude that consuming fermentative microbes such as L. reuteri may offer a tractable public health approach to help counteract the accumulated dietary and genetic carcinogenic events integral in the Westernized diet and lifestyle.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant P30-ES002109)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant RO1CA108854)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant U01 CA164337)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/ijc.28702en_US
dc.rightsCreative Commons Attribution-NonCommercialen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en_US
dc.sourceWiley Blackwellen_US
dc.titleBeneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in miceen_US
dc.typeArticleen_US
dc.identifier.citationLakritz, Jessica R., Theofilos Poutahidis, Tatiana Levkovich, Bernard J. Varian, Yassin M. Ibrahim, Antonis Chatzigiagkos, Sheyla Mirabal, Eric J. Alm, and Susan E. Erdman. “Beneficial Bacteria Stimulate Host Immune Cells to Counteract Dietary and Genetic Predisposition to Mammary Cancer in Mice.” Int. J. Cancer 135, no. 3 (January 10, 2014): 529–540.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Division of Comparative Medicineen_US
dc.contributor.mitauthorVarian, Bernarden_US
dc.contributor.mitauthorLakritz, Jessicaen_US
dc.contributor.mitauthorPoutahidis, Theofilosen_US
dc.contributor.mitauthorLevkovich, Tatianaen_US
dc.contributor.mitauthorIbrahim, Yassinen_US
dc.contributor.mitauthorMirabal, Sheylaen_US
dc.contributor.mitauthorAlm, Eric J.en_US
dc.contributor.mitauthorErdman, Susan E.en_US
dc.relation.journalInternational Journal of Canceren_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLakritz, Jessica R.; Poutahidis, Theofilos; Levkovich, Tatiana; Varian, Bernard J.; Ibrahim, Yassin M.; Chatzigiagkos, Antonis; Mirabal, Sheyla; Alm, Eric J.; Erdman, Susan E.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8294-9364
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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