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Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

Author(s)
Pareja, Kristeen A; Sevier, Carolyn S; Kaiser, Chris; Wang, Jie, S.M. Massachusetts Institute of Technology
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Abstract
Oxidative protein folding in the endoplasmic reticulum (ER) has emerged as a potentially significant source of cellular reactive oxygen species (ROS). Recent studies suggest that levels of ROS generated as a byproduct of oxidative folding rival those produced by mitochondrial respiration. Mechanisms that protect cells against oxidant accumulation within the ER have begun to be elucidated yet many questions still remain regarding how cells prevent oxidant-induced damage from ER folding events. Here we report a new role for a central well-characterized player in ER homeostasis as a direct sensor of ER redox imbalance. Specifically we show that a conserved cysteine in the lumenal chaperone BiP is susceptible to oxidation by peroxide, and we demonstrate that oxidation of this conserved cysteine disrupts BiP's ATPase cycle. We propose that alteration of BiP activity upon oxidation helps cells cope with disruption to oxidative folding within the ER during oxidative stress.
Date issued
2014-07
URI
http://hdl.handle.net/1721.1/96523
Department
Massachusetts Institute of Technology. Department of Biology
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Wang, Jie, Kristeen A Pareja, Chris A Kaiser, and Carolyn S Sevier. “Redox Signaling via the Molecular Chaperone BiP Protects Cells Against Endoplasmic Reticulum-Derived Oxidative Stress.” eLife 3 (July 22, 2014).
Version: Final published version
ISSN
2050-084X

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