dc.contributor.author | Lee, M. N. | |
dc.contributor.author | Ye, C. | |
dc.contributor.author | Villani, A.-C. | |
dc.contributor.author | Raj, T. | |
dc.contributor.author | Li, W. | |
dc.contributor.author | Eisenhaure, Thomas | |
dc.contributor.author | Imboywa, S. H. | |
dc.contributor.author | Chipendo, P. I. | |
dc.contributor.author | Slowikowski, K. | |
dc.contributor.author | Raddassi, K. | |
dc.contributor.author | McCabe, C. | |
dc.contributor.author | Lee, M. H. | |
dc.contributor.author | Frohlich, I. Y. | |
dc.contributor.author | Raychaudhuri, S. | |
dc.contributor.author | Stranger, B. E. | |
dc.contributor.author | Benoist, Christophe | |
dc.contributor.author | De Jager, Philip L. | |
dc.contributor.author | Hacohen, Nir | |
dc.contributor.author | Ran, F. Ann | |
dc.contributor.author | Zhang, Feng | |
dc.contributor.author | Regev, Aviv | |
dc.contributor.author | Hafler, David A. | |
dc.contributor.author | Ward, Lucas D. | |
dc.contributor.author | Kellis, Manolis | |
dc.date.accessioned | 2015-04-22T15:43:50Z | |
dc.date.available | 2015-04-22T15:43:50Z | |
dc.date.issued | 2014-03 | |
dc.date.submitted | 2013-10 | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.issn | 1095-9203 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/96695 | |
dc.description.abstract | Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and computational approaches were applied to determine the effects of genetic variation on the induction of pathogen-responsive genes in human dendritic cells. We identified 121 common genetic variants associated in cis with variation in expression responses to Escherichia coli lipopolysaccharide, influenza, or interferon-β (IFN-β). We localized and validated causal variants to binding sites of pathogen-activated STAT (signal transducer and activator of transcription) and IRF (IFN-regulatory factor) transcription factors. We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection. Our results reveal common alleles that explain interindividual variation in pathogen sensing and provide functional annotation for genetic variants that alter susceptibility to inflammatory diseases. | en_US |
dc.description.sponsorship | National Human Genome Research Institute (U.S.) (Grant P50 HG006193) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). Pioneer Award (DP1 CA174427) | en_US |
dc.description.sponsorship | Howard Hughes Medical Institute | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant HG004037) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). Pioneer Award (DP1 MH100706) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Transformative R01 Grant R01 DK097768) | en_US |
dc.description.sponsorship | W. M. Keck Foundation | en_US |
dc.description.sponsorship | McKnight Foundation | en_US |
dc.description.sponsorship | Merkin, Richard N. | en_US |
dc.description.sponsorship | Damon Runyon Cancer Research Foundation | en_US |
dc.description.sponsorship | Searle Scholars Program | en_US |
dc.description.sponsorship | Simons Foundation | en_US |
dc.language.iso | en_US | |
dc.publisher | American Association for the Advancement of Science (AAAS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1126/science.1246980 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Lee, M. N., C. Ye, A.-C. Villani, T. Raj, W. Li, T. M. Eisenhaure, S. H. Imboywa, et al. “Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells.” Science 343, no. 6175 (March 6, 2014): 1246980–1246980. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | en_US |
dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
dc.contributor.mitauthor | Zhang, Feng | en_US |
dc.contributor.mitauthor | Ran, F. Ann | en_US |
dc.contributor.mitauthor | Regev, Aviv | en_US |
dc.contributor.mitauthor | Hafler, David A. | en_US |
dc.contributor.mitauthor | Ward, Lucas D. | en_US |
dc.contributor.mitauthor | Kellis, Manolis | en_US |
dc.relation.journal | Science | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Lee, M. N.; Ye, C.; Villani, A.-C.; Raj, T.; Li, W.; Eisenhaure, T. M.; Imboywa, S. H.; Chipendo, P. I.; Ran, F. A.; Slowikowski, K.; Ward, L. D.; Raddassi, K.; McCabe, C.; Lee, M. H.; Frohlich, I. Y.; Hafler, D. A.; Kellis, M.; Raychaudhuri, S.; Zhang, F.; Stranger, B. E.; Benoist, C. O.; De Jager, P. L.; Regev, A.; Hacohen, N. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-2782-2509 | |
dc.identifier.orcid | https://orcid.org/0000-0001-8567-2049 | |
dc.identifier.orcid | https://orcid.org/0000-0002-8017-809X | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |