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The Renaissance of Bacillosamine and Its Derivatives: Pathway Characterization and Implications in Pathogenicity

Author(s)
Morrison, Michael James; Imperiali, Barbara
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Abstract
Prokaryote-specific sugars, including N,N′-diacetylbacillosamine (diNAcBac) and pseudaminic acid, have experienced a renaissance in the past decade because of their discovery in glycans related to microbial pathogenicity. DiNAcBac is found at the reducing end of oligosaccharides of N- and O-linked bacterial protein glycosylation pathways of Gram-negative pathogens, including Campylobacter jejuni and Neisseria gonorrhoeae. Further derivatization of diNAcBac results in the nonulosonic acid known as legionaminic acid, which was first characterized in the O-antigen of the lipopolysaccharide (LPS) in Legionella pneumophila. Pseudaminic acid, an isomer of legionaminic acid, is also important in pathogenic bacteria such as Helicobacter pylori because of its occurrence in O-linked glycosylation of flagellin proteins, which plays an important role in flagellar assembly and motility. Here, we present recent advances in the characterization of the biosynthetic pathways leading to these highly modified sugars and investigation of the roles that each plays in bacterial fitness and pathogenicity.
Date issued
2014-02
URI
http://hdl.handle.net/1721.1/96701
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Biochemistry
Publisher
American Chemical Society (ACS)
Citation
Morrison, Michael J., and Barbara Imperiali. “The Renaissance of Bacillosamine and Its Derivatives: Pathway Characterization and Implications in Pathogenicity.” Biochemistry 53, no. 4 (February 4, 2014): 624–638. © 2014 American Chemical Society.
Version: Final published version
ISSN
0006-2960
1520-4995

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