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dc.contributor.authorMercken, Evi M.
dc.contributor.authorCrosby, Seth D.
dc.contributor.authorLamming, Dudley W.
dc.contributor.authorJeBailey, Lellean
dc.contributor.authorKrzysik-Walker, Susan
dc.contributor.authorVillareal, Dennis T.
dc.contributor.authorCapri, Miriam
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorZhang, Yongqing
dc.contributor.authorBecker, Kevin
dc.contributor.authorde Cabo, Rafael
dc.contributor.authorFontana, Luigi
dc.contributor.authorSabatini, David
dc.date.accessioned2015-04-23T17:39:19Z
dc.date.available2015-04-23T17:39:19Z
dc.date.issued2013-06
dc.date.submitted2013-04
dc.identifier.issn14749718
dc.identifier.issn1474-9728
dc.identifier.urihttp://hdl.handle.net/1721.1/96746
dc.description.abstractCaloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by CR in humans. Here, we report that long-term CR in humans inhibits the IGF-1/insulin pathway in skeletal muscle, a key metabolic tissue. We also demonstrate that CR induces dramatic changes of the skeletal muscle transcriptional profile that resemble those of younger individuals. Finally, in both rats and humans, CR evoked similar responses in the transcriptional profiles of skeletal muscle. This common signature consisted of three key pathways typically associated with longevity: IGF-1/insulin signaling, mitochondrial biogenesis, and inflammation. Furthermore, our data identify promising pathways for therapeutic targets to combat age-related diseases and promote health in humans.en_US
dc.description.sponsorshipAmerican Federation for Aging Researchen_US
dc.description.sponsorshipNational Center for Research Resources (U.S.) (Grant UL1 RR024992)en_US
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Grant P30DK056341)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1111/acel.12088en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.sourceWileyen_US
dc.titleCalorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profileen_US
dc.typeArticleen_US
dc.identifier.citationMercken, Evi M., Seth D. Crosby, Dudley W. Lamming, Lellean JeBailey, Susan Krzysik-Walker, Dennis T. Villareal, Miriam Capri, et al. “Calorie Restriction in Humans Inhibits the PI3K/AKT Pathway and Induces a Younger Transcription Profile.” Aging Cell 12, no. 4 (June 5, 2013): 645–651. © 2013 John Wiley & Sons Ltd and the Anatomical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorLamming, Dudley W.en_US
dc.contributor.mitauthorSabatini, David M.en_US
dc.relation.journalAging Cellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMercken, Evi M.; Crosby, Seth D.; Lamming, Dudley W.; JeBailey, Lellean; Krzysik-Walker, Susan; Villareal, Dennis T.; Capri, Miriam; Franceschi, Claudio; Zhang, Yongqing; Becker, Kevin; Sabatini, David M.; de Cabo, Rafael; Fontana, Luigien_US
dc.identifier.orcidhttps://orcid.org/0000-0002-0079-4467
dc.identifier.orcidhttps://orcid.org/0000-0002-1446-7256
mit.licensePUBLISHER_CCen_US


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