Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism
Author(s)Lu, Kun; Mahbub, Ridwan; Cable, Peter Hans; Ru, Hongyu; Parry, Nicola M. A.; Bodnar, Wanda M.; Wishnok, John S.; Styblo, Miroslav; Swenberg, James A.; Fox, James G.; Tannenbaum, Steven Robert; ... Show more Show less
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Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Division of Comparative Medicine
Chemical Research in Toxicology
American Chemical Society (ACS)
Lu, Kun, Ridwan Mahbub, Peter Hans Cable, Hongyu Ru, Nicola M. A. Parry, Wanda M. Bodnar, John S. Wishnok, et al. “Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism.” Chemical Research in Toxicology 27, no. 2 (February 17, 2014): 172–174. © 2014 American Chemical Society.
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