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dc.contributor.authorReynolds, Gretchen
dc.contributor.authorSaygin, Zeynep M.
dc.contributor.authorHofmann, Stefan G.
dc.contributor.authorPollack, Mark
dc.contributor.authorGabrieli, John D. E.
dc.contributor.authorManning, Joshua Brandon
dc.contributor.authorGabrieli, Susan
dc.date.accessioned2015-05-29T13:56:46Z
dc.date.available2015-05-29T13:56:46Z
dc.date.issued2015-04
dc.date.submitted2014-10
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/97112
dc.description.abstractWe investigated differences in the intrinsic functional brain organization (functional connectivity) of the human reward system between healthy control participants and patients with social anxiety disorder. Functional connectivity was measured in the resting-state via functional magnetic resonance imaging (fMRI). 53 patients with social anxiety disorder and 33 healthy control participants underwent a 6-minute resting-state fMRI scan. Functional connectivity of the reward system was analyzed by calculating whole-brain temporal correlations with a bilateral nucleus accumbens seed and a ventromedial prefrontal cortex seed. Patients with social anxiety disorder, relative to the control group, had (1) decreased functional connectivity between the nucleus accumbens seed and other regions associated with reward, including ventromedial prefrontal cortex; (2) decreased functional connectivity between the ventromedial prefrontal cortex seed and lateral prefrontal regions, including the anterior and dorsolateral prefrontal cortices; and (3) increased functional connectivity between both the nucleus accumbens seed and the ventromedial prefrontal cortex seed with more posterior brain regions, including anterior cingulate cortex. Social anxiety disorder appears to be associated with widespread differences in the functional connectivity of the reward system, including markedly decreased functional connectivity between reward regions and between reward regions and lateral prefrontal cortices, and markedly increased functional connectivity between reward regions and posterior brain regions.en_US
dc.description.sponsorshipMassachusetts Institute of Technology (Janet and Sheldon Razin Fellowship)en_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0125286en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourcePublic Library of Scienceen_US
dc.titleAltered Resting-State Functional Connectivity of the Frontal-Striatal Reward System in Social Anxiety Disorderen_US
dc.typeArticleen_US
dc.identifier.citationManning, Joshua, Gretchen Reynolds, Zeynep M. Saygin, Stefan G. Hofmann, Mark Pollack, John D. E. Gabrieli, and Susan Whitfield-Gabrieli. “Altered Resting-State Functional Connectivity of the Frontal-Striatal Reward System in Social Anxiety Disorder.” Edited by Martin Walter. PLOS ONE 10, no. 4 (April 30, 2015): e0125286.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorManning, Joshua Brandonen_US
dc.contributor.mitauthorSaygin, Zeynep M.en_US
dc.contributor.mitauthorGabrieli, John D. E.en_US
dc.contributor.mitauthorGabrieli, Susanen_US
dc.relation.journalPLOS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsManning, Joshua; Reynolds, Gretchen; Saygin, Zeynep M.; Hofmann, Stefan G.; Pollack, Mark; Gabrieli, John D. E.; Whitfield-Gabrieli, Susanen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1158-5692
dc.identifier.orcidhttps://orcid.org/0000-0002-2191-0340
dc.identifier.orcidhttps://orcid.org/0000-0001-8634-4805
mit.licensePUBLISHER_CCen_US


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