Molecular Analysis of TTP, a Key Regulator of TNFα Activity

Author(s)
Johnson, Barbra A.; Blackwell, T. Keith; Yaffe, Michael B
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Abstract
The immediate-early protein tristetraprolin (TTP) is induced by numerous extracellular stimuli and during some apoptotic events. TTP and the related proteins TIS11b and TIS11d (TTP/TIS11 proteins) are members of a family with highly conserved Cys3His zinc fingers that are associated with RNA binding. In mice, lack of TTP causes an inflammatory syndrome that is mediated by TNFα 1, and evidence indicates that TTP can bind and destabilize TNFα and other cytokine mRNAs2. In vitro, all three TTP/TIS11 proteins possess this activity and it is present within the zinc finger region3. Several precedents suggest however that TTP/TIS11 proteins may also be implicated in survival, growth, or apoptotic pathways; a model we have addressed in this study.
Date issued
2001
URI
http://hdl.handle.net/1721.1/97235
Department
Massachusetts Institute of Technology. Department of Biology
Journal
The Scientific World JOURNAL
Publisher
Hindawi Publishing Corporation
Citation
Johnson, Barbra A., Michael Yaffe, and T. Keith Blackwell. “Molecular Analysis of TTP, a Key Regulator of TNFα Activity.” The Scientific World JOURNAL 1 (2001): 38–38.
Version: Final published version
ISSN
1537-744X
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