| dc.contributor.author | Li, Lele | |
| dc.contributor.author | Tong, Rong | |
| dc.contributor.author | Chu, Hunghao | |
| dc.contributor.author | Wang, Weiping | |
| dc.contributor.author | Kohane, Daniel S. | |
| dc.contributor.author | Langer, Robert S | |
| dc.date.accessioned | 2015-06-15T18:50:58Z | |
| dc.date.available | 2015-06-15T18:50:58Z | |
| dc.date.issued | 2014-12 | |
| dc.date.submitted | 2014-07 | |
| dc.identifier.issn | 0027-8424 | |
| dc.identifier.issn | 1091-6490 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/97435 | |
| dc.description.abstract | The in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was prevented by hybridizing the aptamer to a photo-labile complementary oligonucleotide. Upon irradiation at the tumor site, the aptamer was liberated, leading to prolonged intratumoral retention. The relative distribution of the aptamer to the liver and kidney was also significantly decreased, compared to that of the free aptamer. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant GM073626) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | National Academy of Sciences (U.S.) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.1420105111 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | National Academy of Sciences (U.S.) | en_US |
| dc.title | Aptamer photoregulation in vivo | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Li, Lele, Rong Tong, Hunghao Chu, Weiping Wang, Robert Langer, and Daniel S. Kohane. “Aptamer Photoregulation in Vivo.” Proceedings of the National Academy of Sciences 111, no. 48 (November 17, 2014): 17099–17103. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Li, Lele | en_US |
| dc.contributor.mitauthor | Tong, Rong | en_US |
| dc.contributor.mitauthor | Chu, Hunghao | en_US |
| dc.contributor.mitauthor | Wang, Weiping | en_US |
| dc.contributor.mitauthor | Langer, Robert | en_US |
| dc.relation.journal | Proceedings of the National Academy of Sciences | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Li, Lele; Tong, Rong; Chu, Hunghao; Wang, Weiping; Langer, Robert; Kohane, Daniel S. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-7511-3497 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-0419-479X | |
| dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
