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dc.contributor.authorFatouros, Dimitrios G.
dc.contributor.authorLamprou, Dimitrios A.
dc.contributor.authorUrquhart, Andrew J.
dc.contributor.authorYannopoulos, Spyros N.
dc.contributor.authorVizirianakis, Ioannis S.
dc.contributor.authorZhang, Shuguang
dc.contributor.authorKoutsopoulos, Sotirios
dc.date.accessioned2015-06-19T19:15:14Z
dc.date.available2015-06-19T19:15:14Z
dc.date.issued2014-05
dc.date.submitted2014-02
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.urihttp://hdl.handle.net/1721.1/97482
dc.description.abstractAmphiphilic self-assembling peptides are functional materials, which, depending on the amino acid sequence, the peptide length, and the physicochemical conditions, form a variety of nanostructures including nanovesicles, nanotubes, and nanovalves. We designed lipid-like peptides with an aspartic acid or lysine hydrophilic head and a hydrophobic tail composed of six alanines (i.e., ac-A[subscript 6]K-CONH[subscript 2], KA[subscript 6]-CONH[subscript 2], ac-A[subscript 6]D-COOH, and DA[subscript 6]-COOH). The resulting novel peptides have a length similar to biological lipids and form nanovesicles at physiological conditions. AFM microscopy and light scattering analyses of the positively charged lipid-like ac-A[subscript 6]K-CONH[subscript 2], KA[subscript 6]-CONH[subscript 2] peptide formulations showed individual nanovesicles. The negatively charged ac-A[subscript 6]D-COOH and DA[subscript 6]-COOH peptides self-assembled into nanovesicles that formed clusters that upon drying were organized into necklace-like formations of nanovesicles. Encapsulation of probe molecules and release studies through the peptide bilayer suggest that peptide nanovesicles may be good candidates for sustained release of pharmaceutically active hydrophilic and hydrophobic compounds. Lipid-like peptide nanovesicles represent a paradigm shifting system that may complement liposomes for the delivery of diagnostic and therapeutic agents.en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/am501673xen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceAmerican Chemical Societyen_US
dc.titleLipid-like Self-Assembling Peptide Nanovesicles for Drug Deliveryen_US
dc.typeArticleen_US
dc.identifier.citationFatouros, Dimitrios G., Dimitrios A. Lamprou, Andrew J. Urquhart, Spyros N. Yannopoulos, Ioannis S. Vizirianakis, Shuguang Zhang, and Sotirios Koutsopoulos. “Lipid-Like Self-Assembling Peptide Nanovesicles for Drug Delivery.” ACS Applied Materials & Interfaces 6, no. 11 (June 11, 2014): 8184–8189. © 2014 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Center for Biomedical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Center for Bits and Atomsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Media Laboratoryen_US
dc.contributor.mitauthorZhang, Shuguangen_US
dc.contributor.mitauthorKoutsopoulos, Sotiriosen_US
dc.relation.journalACS Applied Materials & Interfacesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsFatouros, Dimitrios G.; Lamprou, Dimitrios A.; Urquhart, Andrew J.; Yannopoulos, Spyros N.; Vizirianakis, Ioannis S.; Zhang, Shuguang; Koutsopoulos, Sotiriosen_US
mit.licensePUBLISHER_POLICYen_US


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