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A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin

dc.contributor.authorLiao, Longyan
dc.contributor.authorLiu, Jenny
dc.contributor.authorMorton, Stephen Winford
dc.contributor.authorHammond, Paula T.
dc.contributor.authorJohnson, Jeremiah A.
dc.contributor.authorDreaden, Erik Christopher
dc.contributor.authorShopsowitz, Kevin
dc.date.accessioned2015-06-22T13:33:24Z
dc.date.available2015-06-22T13:33:24Z
dc.date.issued2014-04
dc.date.submitted2014-03
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.urihttp://hdl.handle.net/1721.1/97487
dc.description.abstractThe synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios of doxorubicin, camptothecin, and cisplatin. To our knowledge, this work provides the first example of orthogonally triggered release of three drugs from single NPs. The highly convergent synthetic approach opens the door to new NP-based combination therapies for cancer.en_US
dc.description.sponsorshipMIT Research Support Committeeen_US
dc.description.sponsorshipLincoln Laboratory. Advanced Concepts Committeeen_US
dc.description.sponsorshipUnited States. Dept. of Defense (Ovarian Cancer Research Program Teal Innovator Award)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award 1F32EB017614-01)en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (Postdoctoral Fellowship)en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (Graduate Fellowship)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ja502011gen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceAmerican Chemical Societyen_US
dc.titleA Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecinen_US
dc.typeArticleen_US
dc.identifier.citationLiao, Longyan, Jenny Liu, Erik C. Dreaden, Stephen W. Morton, Kevin E. Shopsowitz, Paula T. Hammond, and Jeremiah A. Johnson. “A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin.” Journal of the American Chemical Society 136, no. 16 (April 23, 2014): 5896–5899. © 2014 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Soldier Nanotechnologiesen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorLiao, Longyanen_US
dc.contributor.mitauthorLiu, Jennyen_US
dc.contributor.mitauthorDreaden, Erik Christopheren_US
dc.contributor.mitauthorMorton, Stephen Winforden_US
dc.contributor.mitauthorShopsowitz, Kevinen_US
dc.contributor.mitauthorHammond, Paula T.en_US
dc.contributor.mitauthorJohnson, Jeremiah A.en_US
dc.relation.journalJournal of the American Chemical Societyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLiao, Longyan; Liu, Jenny; Dreaden, Erik C.; Morton, Stephen W.; Shopsowitz, Kevin E.; Hammond, Paula T.; Johnson, Jeremiah A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-4954-8443
dc.identifier.orcidhttps://orcid.org/0000-0003-3988-0837
dc.identifier.orcidhttps://orcid.org/0000-0002-8482-9996
dc.identifier.orcidhttps://orcid.org/0000-0001-9157-6491
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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