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dc.contributor.authorBorau, Carlos
dc.contributor.authorKamm, Roger Dale
dc.contributor.authorGarcia-Aznar, Jose Manuel
dc.date.accessioned2015-06-23T13:50:28Z
dc.date.available2015-06-23T13:50:28Z
dc.date.issued2013-06
dc.date.submitted2013-02
dc.identifier.issn1617-7959
dc.identifier.issn1617-7940
dc.identifier.urihttp://hdl.handle.net/1721.1/97510
dc.description.abstractAdherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or muscle contraction. In recognition of this fact, experiments have been conducted to understand cell rigidity-sensing properties under known conditions of the extracellular environment, opening new possibilities for modeling this active behavior. In this work, we provide a physics-based constitutive model taking into account the main structural components of the cell to reproduce its most significant contractile properties such as the traction forces exerted as a function of time and the extracellular stiffness. This model shows how the interplay between the time-dependent response of the acto-myosin contractile system and the elastic response of the cell components determines the mechano-sensing behavior of single cells.en_US
dc.description.sponsorshipEuropean Research Council (Project ERC-2012-StG 306751)en_US
dc.description.sponsorshipSpain. Ministerio de Ciencia e Innovacion (DPI 2009-14115-CO3-01)en_US
dc.description.sponsorshipSpain. Ministerio de Economia y Competitividad (FPI Grant BES-2010-029927)en_US
dc.description.sponsorshipSingapore-MIT Alliance for Research and Technologyen_US
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s10237-013-0508-xen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleA time-dependent phenomenological model for cell mechano-sensingen_US
dc.typeArticleen_US
dc.identifier.citationBorau, Carlos, Roger D. Kamm, and Jose Manuel Garcia-Aznar. “A Time-Dependent Phenomenological Model for Cell Mechano-Sensing.” Biomech Model Mechanobiol 13, no. 2 (June 20, 2013): 451–462.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.mitauthorKamm, Roger Daleen_US
dc.relation.journalBiomechanics and Modeling in Mechanobiologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBorau, Carlos; Kamm, Roger D.; Garcia-Aznar, Jose Manuelen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7232-304X
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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