Supplemental Information for Basic Features of a Cell Electroporation Model: Illustrative Behavior for Two Very Different Pulses

Abstract

To aid understanding we use idealized pulse waveforms. The pulses are trapezoidal, with linear ramps that define the rise and fall times, and a flat peak field strength. Again for simplicity, we label a pulse duration by the duration from start to end. The model can also be used with digitized experimental waveforms. Significant averaging occurs in computing cumulative solute transport, which supports our use of idealized waveforms for understanding basic behavior. There is underlying spatial averaging of U[subscript m(t) behavior that is are distributed over several hundred transmembrane node-pairs, and also integrating the solute transport rates with respect to time.