Nutrient-sensing mechanisms and pathways
Author(s)Efeyan, Alejo; Comb, William C.; Sabatini, David
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The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids, lipids and surrogate metabolites are integrated and coordinated at the organismal level through hormonal signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy. Nutrient-sensing pathways are commonly deregulated in human metabolic diseases.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research; Koch Institute for Integrative Cancer Research at MIT
Nature Publishing Group
Efeyan, Alejo, William C. Comb, and David M. Sabatini. “Nutrient-Sensing Mechanisms and Pathways.” Nature 517, no. 7534 (January 14, 2015): 302–10.
Author's final manuscript