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dc.contributor.authorKumamaru, Kanako K.
dc.contributor.authorGeorge, Elizabeth
dc.contributor.authorRybicki, Frank J.
dc.contributor.authorLedesma-Carbayo, Maria J.
dc.contributor.authorGonzalez Serrano, German
dc.contributor.authorJimenez-Carretero, Daniel
dc.contributor.authorRodriguez-Lopez, Sara
dc.contributor.authorSan Jose Estepar, Raul
dc.date.accessioned2015-08-20T18:00:15Z
dc.date.available2015-08-20T18:00:15Z
dc.date.issued2015-05
dc.date.submitted2014-12
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/98131
dc.description.abstractBackground and Purpose Right Ventricular to Left Ventricular (RV/LV) diameter ratio has been shown to be a prognostic biomarker for patients suffering from acute Pulmonary Embolism (PE). While Computed Tomography Pulmonary Angiography (CTPA) images used to confirm a clinical suspicion of PE do include information of the heart, a numerical RV/LV diameter ratio is not universally reported, likely because of lack in training, inter-reader variability in the measurements, and additional effort by the radiologist. This study designs and validates a completely automated Computer Aided Detection (CAD) system to compute the axial RV/LV diameter ratio from CTPA images so that the RV/LV diameter ratio can be a more objective metric that is consistently reported in patients for whom CTPA diagnoses PE. Materials and Methods The CAD system was designed specifically for RV/LV measurements. The system was tested in 198 consecutive CTPA patients with acute PE. Its accuracy was evaluated using reference standard RV/LV radiologist measurements and its prognostic value was established for 30-day PE-specific mortality and a composite outcome of 30-day PE-specific mortality or the need for intensive therapies. The study was Institutional Review Board (IRB) approved and HIPAA compliant. Results The CAD system analyzed correctly 92.4% (183/198) of CTPA studies. The mean difference between automated and manually computed axial RV/LV ratios was 0.03±0.22. The correlation between the RV/LV diameter ratio obtained by the CAD system and that obtained by the radiologist was high (r=0.81). Compared to the radiologist, the CAD system equally achieved high accuracy for the composite outcome, with areas under the receiver operating characteristic curves of 0.75 vs. 0.78. Similar results were found for 30-days PE-specific mortality, with areas under the curve of 0.72 vs. 0.75. Conclusions An automated CAD system for determining the CT derived RV/LV diameter ratio in patients with acute PE has high accuracy when compared to manual measurements and similar prognostic significance for two clinical outcomes.en_US
dc.description.sponsorshipMadrid-MIT M+Vision Consortiumen_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0127797en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourcePublic Library of Scienceen_US
dc.titleAutomated Axial Right Ventricle to Left Ventricle Diameter Ratio Computation in Computed Tomography Pulmonary Angiographyen_US
dc.typeArticleen_US
dc.identifier.citationGonzalez, German, Daniel Jimenez-Carretero, Sara Rodriguez-Lopez, Kanako K. Kumamaru, Elizabeth George, Raul San Jose Estepar, Frank J. Rybicki, and Maria J. Ledesma-Carbayo. “Automated Axial Right Ventricle to Left Ventricle Diameter Ratio Computation in Computed Tomography Pulmonary Angiography.” Edited by Diego Fraidenraich. PLoS ONE 10, no. 5 (May 22, 2015): e0127797.en_US
dc.contributor.departmentMadrid-MIT M+Vision Consortiumen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.mitauthorGonzalez Serrano, Germanen_US
dc.relation.journalPLOS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGonzalez, German; Jimenez-Carretero, Daniel; Rodriguez-Lopez, Sara; Kumamaru, Kanako K.; George, Elizabeth; San Jose Estepar, Raul; Rybicki, Frank J.; Ledesma-Carbayo, Maria J.en_US
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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