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dc.contributor.authorLi, Matthew
dc.contributor.authorMilner, Danny A.
dc.contributor.authorCima, Michael J.
dc.date.accessioned2015-08-20T18:10:36Z
dc.date.available2015-08-20T18:10:36Z
dc.date.issued2015-05
dc.date.submitted2014-02
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/98133
dc.description.abstractAtherosclerosis and malignancy are pervasive pathological conditions that account for the bulk of morbidity and mortality in developed countries. Our current understanding of the patholobiology of these fundamental disorders suggests that inflammatory processes may differentially affect them; thus, atherosclerosis can be largely driven by inflammation, where as cancer often flourishes as inflammatory responses are modulated. A corollary of this hypothesis is that cancer (or its treatment may significantly attenuate atherosclerotic disease by diminishing host inflammatory response, suggesting potential therapeutic approaches. To evaluate the relationship between cancer and cardiovascular atherosclerotic disease, we assessed 1,024 autopsy reports from Brigham and Women’s Hospital and performed correlative analyses on atherosclerotic severity and cancer prevalence. In gender- and age-matched populations, there is a statistically significant inverse correlation between history of malignancy and autopsy-proven atherosclerotic disease. In a second analysis, we evaluated 147,779 patients through analysis of the Harvard Catalyst SHRINE database and demonstrated a reduced non-coronary atherosclerotic disease rate: control (27.40%), leukemia/lymphoma (12.57%), lung (17.63%), colorectal (18.17%), breast (9.79%), uterus/cervix (11.47%), and prostate (18.40%). We herein report that, based on two separate medical records analysis, an inverse correlation between cancer and atherosclerosis. Furthermore, this correlation is not uniformly associated with anti-neoplastic treatment, suggesting that the inverse relationship may be in part attributable to an individual’s intrinsic inflammatory propensity, and/or to inflammation-modulatory properties of neoplasms.en_US
dc.description.sponsorshipHarvard University (Shared Health Research Information Network Prize)en_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0126855en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourcePublic Library of Scienceen_US
dc.titleIf It’s Not One Thing, It’s Another: An Inverse Relationship of Malignancy and Atherosclerotic Diseaseen_US
dc.typeArticleen_US
dc.identifier.citationLi, Matthew, Michael J Cima, and Danny A. Milner. “If It’s Not One Thing, It’s Another: An Inverse Relationship of Malignancy and Atherosclerotic Disease.” Edited by Francesco Cappello. PLoS ONE 10, no. 5 (May 22, 2015): e0126855.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Lemelson-MIT Awards Programen_US
dc.contributor.mitauthorLi, Matthewen_US
dc.contributor.mitauthorCima, Michael J.en_US
dc.relation.journalPLOS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLi, Matthew; Cima, Michael J; Milner, Danny A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-2379-6139
dc.identifier.orcidhttps://orcid.org/0000-0001-9296-2220
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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