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The Evolution of the Ribosome and the Genetic Code

Author(s)
Hartman, Hyman; Smith, Temple
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Abstract
The evolution of the genetic code is mapped out starting with the aminoacyl tRNA-synthetases and their interaction with the operational code in the tRNA acceptor arm. Combining this operational code with a metric based on the biosynthesis of amino acids from the Citric acid, we come to the conclusion that the earliest genetic code was a Guanine Cytosine (GC) code. This has implications for the likely earliest positively charged amino acids. The progression from this pure GC code to the extant one is traced out in the evolution of the Large Ribosomal Subunit, LSU, and its proteins; in particular those associated with the Peptidyl Transfer Center (PTC) and the nascent peptide exit tunnel. This progression has implications for the earliest encoded peptides and their evolutionary progression into full complex proteins.
Date issued
2014-05
URI
http://hdl.handle.net/1721.1/98185
Department
Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences
Journal
Life
Publisher
MDPI AG
Citation
Hartman, Hyman, and Temple Smith. “The Evolution of the Ribosome and the Genetic Code.” Life 4, no. 2 (May 20, 2014): 227–249.
Version: Final published version
ISSN
2075-1729

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