The Evolution of the Ribosome and the Genetic Code
Name
Hartman-2014-The evolution of the.pdf
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708.81 KB
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Adobe PDF
Checksum (MD5)
a8aa3b98bda7f96a3d1a7476060b1c02
Author(s)
Hartman, Hyman
Smith, Temple
Date Issued
May 2014
Journal
Life
Publisher
MDPI AG
Citation
Hartman, Hyman, and Temple Smith. “The Evolution of the Ribosome and the Genetic Code.” Life 4, no. 2 (May 20, 2014): 227–249.
Version
Final published version
Abstract
The evolution of the genetic code is mapped out starting with the aminoacyl tRNA-synthetases and their interaction with the operational code in the tRNA acceptor arm. Combining this operational code with a metric based on the biosynthesis of amino acids from the Citric acid, we come to the conclusion that the earliest genetic code was a Guanine Cytosine (GC) code. This has implications for the likely earliest positively charged amino acids. The progression from this pure GC code to the extant one is traced out in the evolution of the Large Ribosomal Subunit, LSU, and its proteins; in particular those associated with the Peptidyl Transfer Center (PTC) and the nascent peptide exit tunnel. This progression has implications for the earliest encoded peptides and their evolutionary progression into full complex proteins.
MIT Department
Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences
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Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/life4020227
