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dc.contributor.authorMurn, Jernej
dc.contributor.authorZarnack, Kathi
dc.contributor.authorYang, Yawei J.
dc.contributor.authorDurak, Omer
dc.contributor.authorMurphy, Elisabeth A.
dc.contributor.authorCheloufi, Sihem
dc.contributor.authorGonzalez, Dilenny M.
dc.contributor.authorTeplova, Marianna
dc.contributor.authorCurk, Tomaž
dc.contributor.authorZuber, Johannes
dc.contributor.authorPatel, Dinshaw J.
dc.contributor.authorUle, Jernej
dc.contributor.authorLuscombe, Nicholas M.
dc.contributor.authorTsai, Li-Huei
dc.contributor.authorWalsh, Christopher A.
dc.contributor.authorShi, Yang
dc.date.accessioned2015-09-08T16:28:42Z
dc.date.available2015-09-08T16:28:42Z
dc.date.issued2015-03
dc.date.submitted2015-01
dc.identifier.issn0890-9369
dc.identifier.issn1549-5477
dc.identifier.urihttp://hdl.handle.net/1721.1/98393
dc.description.abstractCellular morphology is an essential determinant of cellular function in all kingdoms of life, yet little is known about how cell shape is controlled. Here we describe a molecular program that controls the early morphology of neurons through a metazoan-specific zinc finger protein, Unkempt. Depletion of Unkempt in mouse embryos disrupts the shape of migrating neurons, while ectopic expression confers neuronal-like morphology to cells of different nonneuronal lineages. We found that Unkempt is a sequence-specific RNA-binding protein and identified its precise binding sites within coding regions of mRNAs linked to protein metabolism and trafficking. RNA binding is required for Unkempt-induced remodeling of cellular shape and is directly coupled to a reduced production of the encoded proteins. These findings link post-transcriptional regulation of gene expression with cellular shape and have general implications for the development and disease of multicellular organisms.en_US
dc.language.isoen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1101/gad.258483.115en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en_US
dc.sourceCold Spring Harbor Laboratory Pressen_US
dc.titleControl of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempten_US
dc.typeArticleen_US
dc.identifier.citationMurn, Jernej, Kathi Zarnack, Yawei J. Yang, Omer Durak, Elisabeth A. Murphy, Sihem Cheloufi, Dilenny M. Gonzalez, et al. “Control of a Neuronal Morphology Program by an RNA-Binding Zinc Finger Protein, Unkempt.” Genes Dev. 29, no. 5 (March 1, 2015): 501–512.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.mitauthorDurak, Omeren_US
dc.contributor.mitauthorTsai, Li-Hueien_US
dc.relation.journalGenes & Developmenten_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMurn, Jernej; Zarnack, Kathi; Yang, Yawei J.; Durak, Omer; Murphy, Elisabeth A.; Cheloufi, Sihem; Gonzalez, Dilenny M.; Teplova, Marianna; Curk, Tomaž; Zuber, Johannes; Patel, Dinshaw J.; Ule, Jernej; Luscombe, Nicholas M.; Tsai, Li-Huei; Walsh, Christopher A.; Shi, Yangen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1262-0592
dc.identifier.orcidhttps://orcid.org/0000-0001-8426-6188
mit.licensePUBLISHER_CCen_US


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